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She wonders what follow-up she should have after the surgery to manage her cancer risk. The randomised controlled trial, ‘Psychosexual conseqUences of Risk‐reducing Salpingo‐oophorectomy in BRCA1/2 mUtation carriErs’ (PURSUE) study is an open‐label trial and was approved by the Medical Ethical Committee of the University Medical Center Groningen on 14 November 2014 (registration no. NL46796.042.14). Risk-reducing salpingo-oophorectomy Risk-reducing salpingo-oophorectomy (RR-SO) is the surgical removal of the ovaries and the Fallopian tubes which connect the uterus (womb) with the ovary. Both types of tissue are at increased risk in women with a family history of ovarian cancer or an ovarian cancer risk gene mutation. Prophylactic risk-reducing salpingo-oophorectomy (RRSO) is an important option for the high-risk population to consider. Women with BRCA1/2 mutations who undergo salpingo-oophorectomy have lower all-cause mortality rates than women in the same population who do not undergo this procedure.

Risk reducing salpingo-oophorectomy

We reviewed studies pertaining to prophylactic bilateral salpingo-oophorectomy in women at average risk of ovarian cancer who are undergoing hysterectomy for benign disease.

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This is known as a risk-reducing salpingo-oophorectomy. This Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is an important option for reducing the risk of developing epithelial ovarian and fallopian tube cancer in patients with a hereditary ovarian cancer syndrome [ 1 ]. Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is an important option for reducing the risk of developing epithelial ovarian and fallopian tube cancer in patients with a hereditary ovarian cancer syndrome [ 1 ].

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Objective To assess the association of RRSO with the risk of breast cancer in women with BRCA1 and BRCA2 pathogenic variants. The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain.
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based on it – to have a bilateral mastectomy and salpingo-oophorectomy. Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation. N Engl J Med, 346:1609–15. Kauff, N.D. et al.

(2002). Risk-reducing 169. Kauff ND, Barakat RR. Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2. Journal of clinical oncology : official Erratum: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: An international prospective cohort of BRCA1 and BRCA2 mutation 6.1 Screening av asymtomatiska kvinnor utan påvisad ärftlig risk . of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. Prophylactic bilateral salpingo-oophorectomy compared with Gender affirmation surgery for gender dysphoria-effects and risks. reconstruction (including penile prosthesis), hysterectomy + salpingo- for hysterectomies has increased and has, in combination with reduced access to.
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She is concerned about health outcomes, including menopause and quality of life after surgery. She wonders what follow-up she should have after the surgery to manage her cancer risk. The randomised controlled trial, ‘Psychosexual conseqUences of Risk‐reducing Salpingo‐oophorectomy in BRCA1/2 mUtation carriErs’ (PURSUE) study is an open‐label trial and was approved by the Medical Ethical Committee of the University Medical Center Groningen on 14 November 2014 (registration no. NL46796.042.14). Risk-reducing salpingo-oophorectomy Risk-reducing salpingo-oophorectomy (RR-SO) is the surgical removal of the ovaries and the Fallopian tubes which connect the uterus (womb) with the ovary. Both types of tissue are at increased risk in women with a family history of ovarian cancer or an ovarian cancer risk gene mutation.

2009-01-21 · In this issue of the Journal, Rebbeck et al. have provided us with a meticulously executed, up-to-date meta-analysis that quantifies the reductions in the risks of breast and ovarian/fallopian tube cancer that follow risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 and BRCA2 (BRCA1/2) mutation carriers. A recent meta-analysis suggests a 79% reduction in ovarian/fallopian tube cancer risk and a 53% reduction in breast cancer risk after oophorectomy in these women 6. A prospective multicenter study of 2482 women with BRCA1/2mutations reported that these risk reductions translated into lower breast and ovarian cancer mortality 7. Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is an important option for reducing the risk of developing epithelial ovarian and fallopian tube cancer in patients with a hereditary ovarian cancer syndrome [ 1 ]. Risk-reducing surgery includes bilateral removal of the tubes as well as the ovaries because some apparent ovarian cancers are Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is an important option for reducing the risk of developing epithelial ovarian and fallopian tube cancer in patients with a hereditary ovarian cancer syndrome [ 1 ]. 2018-12-06 · This is known as a risk-reducing salpingo-oophorectomy.
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Mai PL, Miller A, Gail MH, Skates S, Lu K, Sherman ME, Ioffe OB, Rodriguez G, Cohn DE, Boggess J, Rutherford T, Kauff ND, Rader JS, Phillips KA, DiSilvestro PA, Olawaiye AB, Ridgway MR, Greene MH, Piedmonte M, Walker JL. Risk-reducing salpingo-oophorectomy Participants were recruited through surgical records from three university hospitals in Norway. We identiﬁed 503 women at increased risk of hereditary breast and ovarian cancer who underwent RRSO in the period 1978–2005. The women were invited to participate by a mailed ques- 2019-05-25 · Introduction The management of Serous Tubal Intraepithelial Carcinoma (STIC) found at the time of Risk-Reducing Salpingo-Oophorectomy (RRSO) remains unclear. We set out to analyse the incidence of peritoneal carcinomas developed after prophylactic surgery and to formulate further guidance for these patients. Methods This is a retrospective study of 300 consecutive RRSO performed at the Royal Background: Risk-reducing salpingo-oophorectomy (RRSO) is the most effective intervention to prevent ovarian cancer (OC).

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Risk-reducing surgery includes bilateral removal of the tubes as well as the ovaries because some apparent ovarian cancers are Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is an important option for reducing the risk of developing epithelial ovarian and fallopian tube cancer in patients with a hereditary ovarian cancer syndrome [ 1 ]. 2018-12-06 · This is known as a risk-reducing salpingo-oophorectomy. This surgery has been shown to be highly effective in lowering the risk of breast and ovarian cancer. Learn more about the causes and risk Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. RRSO = risk-reducing salpingo-oophorectomy; ROCA = risk of ovarian cancer algorithm. *Participants with previous bilateral breast cancer, unilateral breast cancer, and contralateral risk-reducing mastectomy or bilateral risk-reducing mastectomy prior to enrollment were excluded from the breast cancer incidence rate estimates.